Naomi Chesler Lab, Engineering cardiopulmonary health. Right ventricular failure (RVF) is understudied compared to left ventricular failure (LVF) but worsens morbidity and mortality from LVF and also displays intriguing and poorly understood sex dependence. The CheslerLab strives to better understand and prevent RVF by focusing on three aspects of cardiopulmonary physiology and pathophysiology: right ventricular function, pulmonary vascular blood flow dynamics, and how changes in the large and small pulmonary arteries alter blood flow dynamics and thus right ventricular function.  We also seek to understand sex differences in incidence and progression of RVF.  The CheslerLab combines clinical, preclinical, in vitro, and in silico approaches to achieve these aims.